THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
发明人:
PRIEBE, WALDEMAR,FOKT, IZABELA,SZYMANSKI, SLAWOMIR,MADDEN, TIMOTHY,MYERS, JEFFREY,CONRAD, CHARLES
申请号：
ES12162385
公开号：
ES2533383T3
申请日:
2007.04.02
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound selected from the group consisting of: ** Formula ** in which R1 is -H or cyano and R2 is C3-C7 cycloalkyl substituted with heteroatom； ** Formula ** in which X1 is halo and R3 is C3 cycloalkyl- C7 substituted with heteroatom； ** Formula ** in which: X3 is halo or C1-C10 alkyl or C1-C10 alkoxy substituted with heteroatom or not substituted with heteroatom, R5 is -H or cyano, and R6 is C3-C7 cycloalkyl not substituted with heteroatom； ** Formula ** in which: X4 is halo or is C1-C10 alkyl or C1-C10 alkoxy substituted with heteroatom or not substituted with heteroatom, R7 is -H or cyano, and R8 is C3- cycloalkyl C7 not substituted with heteroatom； ** Formula ** in which: X5 is C1-C10 alkyl substituted with heteroatom or not substituted with heteroatom, ** Formula ** R9 is -H or cyano, and R10 is C3-C7 cycloalkyl no substituted with heteroatom； and a pharmaceutically acceptable salt or tautomer thereof.Un compuesto seleccionado del grupo constituido por:**Fórmula** en la que R1 es -H o ciano y R2 es cicloalquilo C3-C7 sustituido con heteroátomo；**Fórmula** en la que X1 es halo y R3 es cicloalquilo C3-C7 sustituido con heteroátomo；**Fórmula** en la que: X3 es halo o alquilo C1-C10 o alcoxi C1-C10 sustituidos con heteroátomo o no sustituidos con heteroátomo, R5 es -H o ciano, y R6 es cicloalquilo C3-C7 no sustituido con heteroátomo；**Fórmula** en la que: X4 es halo o es alquilo C1-C10 o alcoxi C1-C10 sustituidos con heteroátomo o no sustituidos con heteroátomo, R7 es -H o ciano, y R8 es cicloalquilo C3-C7 no sustituido con heteroátomo；**Fórmula** en la que: X5 es alquilo C1-C10 sustituido con heteroátomo o no sustituido con heteroátomo,**Fórmula** R9 es -H o ciano, y R10 es cicloalquilo C3-C7 no sustituido con heteroátomo； y una sal o un tautómero farmacéuticamente aceptables del mismo.
