Compound of formula (Ia) ** Pharmaceutically acceptable formula ** thereof, wherein: L1 is a) C3-C7 alkylene, C3-C7 alkenylene or C3-C7 alkynylene, wherein C3-C7 alkylene, C3 alkenylene -C7 or C3-C7 alkynylene are each optionally substituted with 1, 2, 3 or 4 fluoro substituents； ) - (CH2) t-G- (CH2) p-； where t is 0, 1 or 2, p is 0, 1, 2 or 3, and t + p>； = 0, 1, 2, 3 or 4； o) - (CH2) n-G1- (CH2) p-, - (CH2) n-G2- (CH2) p-, - (CH2) nC≡ - (CH2) nC (R13)>； = C (R13) -G2-, in which n is 1, 2, 3, 4 or 5, p is 0, 1, 2 or 3, and n + p>； = 1, 2, 3, 4, 5 or 6； G is ** Formula ** or ** Formula ** G1 is O, C (O), S, S (O), S (O) 2, or NR8； wherein R8 is H, C1-C4 alkyl or C1-C4 alkylcarbonyl； G2 ** Formula ** is where G2 is optionally substituted with 1, 2 or 3 substituents selected from the group consisting of C1-C4 alkyl, C1-C3 haloalkyl, cyano, halogen, C1-C3 alkoxy and C1- haloalkoxy C3； R1 is COOR10, CONR10R11, CH2OR10, SO3R10, SO2NR10R11, PO (OR10) 2 or tetrazol-5-yl； R10 is H, C1-C4 alkyl or aryl； ** Formula ** R11 is H, C1-C4 alkyl, COR12, OR10 or SO2R12； R12 is C1-C4 alkyl； R13, in each case, is independently H or C1-C4 alkyl； L4 is -C (R2) 2-C (R3) 2-, -C (R2)>； = C (R3) -, -C≡C-, or ** Formula ** in which R2 and R3 are each H, CH3, fluorine or chlorine； L2 is -CH2- or a link； R4 and R5 are each independently H, F, CF3 or C1-C4 alkyl； or R4 and R5 together with the carbon to which they are attached form a C3-C5 cycloalkyl, ** Formula ** R6 is aryl, heteroaryl, C3-C10 alkyl, C3-C10 alkenyl, C3-C10 alkynyl, C3-C10 haloalkyl, C3-C10 haloalkenyl, C3-C10 haloalkynyl, or L3-R7； wherein the aryl and heteroaryl are optionally substituted with 1, 2, 3 or 4 substituents selected from the group consisting of C1-C4 alkyl, C1-C3 haloalkyl, cyano, halogen, C1-C3 alkoxy, C1-C3 haloalkoxy； and -C1-C3 alkylene-C1-C3 alkoxy； and wherein the C3-C10 alkyl, C3-C10 alkenyl, C3-C10 alkynyl, C3-C10 haloalkyl, C3-C10 haloalkenyl and C3-C10 haloalkynyl are optionally substituted with
