PROBLEM TO BE SOLVED: To provide a CRF receptor antagonist which meets the points of pharmacological activity, dosage, safety and the like and effectively acts in clinical trials.SOLUTION: The compound is represented by formula (I) (wherein R1 is a methoxy group, an ethyl group, a methylthio group or the like R2, R3, and R4 are each hydrogen, a halogen or the like R5 and R6 are each a group represented by the formula: -X5-X6-X7 and Ar is a phenyl group, a pyridyl group or the like) and includes its salt and a hydrate thereof.COPYRIGHT: (C)2009,JPO&INPIT【課題】医薬として、薬理活性、投与量、安全性等の点を満足させ臨床で有効に作用するCRF受容体アンタゴニストの提供。【解決手段】一般式〔式中、R1はメトキシ基、エチル基、メチルチオ基等を意味し、R2、R3およびR4はそれぞれ水素原子、ハロゲン原子等を意味し、R5およびR6はそれぞれ式-X5-X6-X7で表わされる基を意味し、Arはフェニル基、ピリジル基等を意味する。〕で表わされる化合物もしくはその塩またはそれらの水和物。【選択図】なし
