An example of an internal covering membrane of a duodenum that can be madefrombiocompatible materials via electrospinning technology is described herein.After theinternal covering membrane of the duodenum is implanted into the duodenum, itcannot only prevent food from contacting with the intestinal mucosa in anatomy,but alsomake no affect on the functions of the intestinal mucosa cells in physiology.Theinternal covering membrane can be made by blending electrospinning or/andmultilayer electrospinning or/and core-shell electrospinning or/and dryelectrospinning, and can be used to manufacture medical devices for treatingdiabetesand obesity, while reducing damage, preventing falling-off, avoiding removalandinhibiting bounce.