An internal covering membrane of duodenum can be made from biocompatible materials via electrospinning technology is described herein. After the internal covering membrane of duodenum is implanted into the duodenum, it can not only prevent food from contacting with the intestinal mucosa in anatomy, but also make no affect on the functions of intestinal mucosa cells in physiology. The internal covering membrane can be made by blending electrospinning or/and multilayer electrospinning or/and core-shell electrospinning or/and dry electrospinning, and can be used to manufacture medical devices for treating diabetes and obesity, with functions of reducing damage, preventing falling-off, avoiding removal and inhibiting bounce.
