WOO, JONG SOO,PARK, JAE HYUN,KIM, YONG IL,NA, YOUNG JUN,KIM, MIN JUNG,LEE, YUN AH
申请号：
EP11737251
公开号：
EP2531180A4
申请日:
2011.01.18
申请国别(地区):
EP
年份:
2014
代理人:
摘要：
An oral complex composition which comprises (i) a core comprising a swellable hydrogel-forming agent and pseudoephedrine, or a pharmaceutically acceptable salt thereof； (ii) a first coating layer encasing the core which comprises a water-soluble substance； and (iii) a second coating layer deposited on the first coating layer which comprises levocetirizine or a pharmaceutically acceptable salt thereof together with polyvinylalcohol, povidone, polyvinylalcohol-polyethyleneglycol graft copolymer or a mixture thereof, has an improved levocetirizine releasing rate and does not show a delayed release behavior even after a long storage period. Accordingly, the inventive oral complex composition is useful for treating perennial or seasonal allergic diseases including nasal obstruction, sneezing, and rhinorrhea.
