ЛИМ Сун Ин (KR),ДЖАН Мьюн Хьюн (KR),КИМ Дае Джин (KR),ДЖУН Сун Юб (KR),КВОН Се Чан (KR)
申请号：
RU2013152687/10
公开号：
RU2013152687A
申请日:
2012.06.01
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. multimer non-peptidyl polymer-insulin comprising two or more non-peptidyl polymer-conjugate of insulin, obtained by binding non-peptidyl polymer and insulin through a covalent bond, wherein the conjugates are complexed with cobalt ion to form multimera.2. The multimer according to claim 1, wherein the conjugate is insulin-non-peptidyl polymer obtained by binding non-peptidyl polymer with the A-chain amino terminus, the amino terminus of the B-chain or a lysine at position 29 of insulin B-chain by a covalent svyazi.3. The multimer according to claim 1, wherein the insulin is a naturally occurring insulin, insulin variant obtained by substitutions, additions, deletions, modifications, or combinations thereof in the amino acid sequences of natural insulin, insulin derivative or its fragment.4. The multimer according to claim 1, wherein a non-peptidyl polymer is selected from the group consisting of biodegradable polymers, lipid polymers, chitins, hyaluronic acid and their kombinatsiy.5. The multimer according to claim 4, wherein the biodegradable polymer is selected from the group consisting of polyethylene glycol, polypropylene glycol, copolymer of ethylene glycol and propylene glycol, polyoxyethylated polyol, polyvinyl alcohol, polysaccharide, dextran, polyvinyl ethyl ether, polylactic acid and polylactic-glycolic kisloty.6. The multimer according to claim 5, wherein the biodegradable polymer is a polietilenglikol.7. The multimer of claim 1 wherein the reactive group of non-peptidyl polymer is covalently bound to insulin is selected from the group consisting of aldehyde, propionaldegidnogo, buthyl aldehyde, maleimide and succinimide proizvodnogo.8. The multimer according to claim 1, wherein konyuga1. Мультимер непептидильный полимер-инсулин, содержащий два или более конъюгата непептидильный полимер-инсулин, полученных путем связывания непептидильного полимера и инсулина посредством ковалентной связи, где конъюгаты образуют комплекс с ионом кобальта с образованием
