BARSANTI, PAUL A.,HU, CHENG,JIN, JEFF,KEYES, ROBERT,KUCEJKO, ROBERT,LIN, XIAODONG,PAN, YUE,PFISTER, KEITH B.,SENDZIK, MARTIN,WAN, LIFENG
申请号：
PE0001192012
公开号：
PE11272012A1
申请日:
2010.07.28
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
Refers to a compound of formula I, where A1 is cn CH3, N, C -, C -, among others A2 is N (o) CH3, N, C, C - o, - Halogen, among others A3 is CH3, N, C - C - C - i CN, among others A4 is link, SO2, NH3, among others link l is c1-c4 alkyl, optionally substituted, cicloalqulo C3 C6, het Erocicloalquilo C3 C6, alquenilo c2-c4 r1 is X - X is link, R16C1-c4 alkyl alkyl R16 is C1 - C6 C3 C6 branched alkyl, cycloalkyl, aryl, C3, C8, among others R2 is alkyl of C1 - C6 C3 C6 alkyl, optionally substituted, optionally substituted aryl, among others R3 is hydroxyl h, halogen, alkyl, cyano, among others R4 and R5 are Each h, Hydroxy So, halogeno, cyano, c1-c4 alkyl, among others.Preferred compounds are: n2 - (trans-4 - Cyclohexyl - amino) - 5 - chlorine - 3.5 - difluoro - N6 - (Tetrahydro - 2H - piran - 4 - yl) methyl) - 2,4 - bipiridin - 2, 6 - diamine 5 - Chloro - 5 - fluoro - N2 - (trans-4 - (2 - (Methyl sulfonyl) ethyl amino) - N6 - (Cyclohexyl) - tetrahydro - 2H - piran - 4 - yl) methyl) - 2,4 - bipiridin - 2, 6 - among other diamine S. such compounds are useful in the treatment of a disease or condition mediated by Cdk9REFERIDA A UN COMPUESTO DE FORMULA I, DONDE A1 ES N, CH3, C-CN, C-OH, ENTRE OTROS A2 ES N, N(O), CH3, C-OH, C-HALOGENO, ENTRE OTROS A3 ES N, CH3, C-OH, C-ALQUILO, C-CN, ENTRE OTROS A4 ES ENLACE, SO2, O, NH3, ENTRE OTROS L ES ENLACE, ALQUILO C1-C4 OPCIONALMENTE SUSTITUIDO, CICLOALQULO C3-C6, HETEROCICLOALQUILO C3-C6, ALQUENILO C2-C4 R1 ES X-R16 X ES ENLACE, ALQUILO C1-C4 R16 ES ALQUILO C1-C6, ALQUILO C3-C6 RAMIFICADO, CICLOALQUILO C3-C8, ARILO, ENTRE OTROS R2 ES ALQUILO C1-C6, ALQUILO C3-C6 OPCIONALMENTE SUSTITUIDO, ARILO OPCIONALMENTE SUSTITUIDO, ENTRE OTROS R3 ES H, HIDROXILO, CIANO, HALOGENO, ALQUILO, ENTRE OTROS R4 Y R5 SON CADA UNO H, HIDROXILO, CIANO, HALOGENO, ALQUILO C1-C4, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N2-(TRANS-4-AMINO-CICLOHEXIL)-5-CLORO-3,5-DIFLUORO-N6-((TETRAHIDRO-2H-PIRAN-4-IL)-METIL)-2,4-BIPIRIDIN-2,6-DIAMINA 5-CLORO-5-FLUORO-N2-(TRAN
