BROWN, Sean P.,LI, Yunxiao,LIZARZABURU, Mike Elias,LUCAS, Brian S.,PARAS, Nick A.,TAYGERLY, Joshua,VIMOLRATANA, Marc,WANG, Xianghong,YU, Ming,ZANCANELLA, Manuel,ZHU, Liusheng,GONZALEZ BUENROSTRO, Ana
申请号：
PE2017000362
公开号：
PE20170892A1
申请日:
2015.08.28
申请国别(地区):
PE
年份:
2017
代理人:
摘要：
It refers to a formula compound (I), where B is a single or double chemical bond, possibly cis or trans； R is halogen； R1 is h, C1-C6 or - (CH2CH2O) nch3； n is 1, 2, 3 or 4； R2, R2A and R3 are h or C1-C6； R3a is h, C1-C6 tar, c1-c3-c6 or (CH2) mcyclo-c3, C3, or c3-c3.13'dioxin (1s, 3'r, 6'r, 7's, 8'e) - 6-chloro-7-hydroxy-11-dimethyl-3, 4-dihydro-2h, 15'h-helix [naftelen-1, 22 - [20] oxa [13] thia [1, 14] - pentachlorobenzene [14.7.2.03, 6.019.24] - tetrahedron [8, 16, 18, 24]. You also mean a composer This compound inhibits the protein of Mcl-1 and is effective in the treatment of breast cancer and skin cancer.Se refiere a un compuesto de formula (I) en donde b que es una ligacion quimica individual o doble que puede ser cis o trans； R es halo； R1 es H, alquilo C1-C6 o -(CH2CH2O)nCH3； n es 1, 2, 3 o 4； R2, R2A y R3 es H o alquilo C1-C6； R3A es H, alquilo C1-C6, cicloalquilo C3-C6 o (CH2)m-cicloalquilo C3-C6； m es 1, 2, 3 o 4.Es un seleccionado: 13´, 13´-dioxido de (1S, 3´R, 6´R, 7´S, 8´E)-6-cloro-7´-hidroxi-11´-11´-dimetil-3,4-dihidro-2H, 15´H-espiro[naftalen-1, 22´-[20]oxa[13]thia[1, 14]-diazatetraciclo[14.7.2.03,6.019,24]pentacosa[8,16,18,24]tetraen-15´-ona. Tambien se refiere a una composicion. Dicho compuesto inhibe la proteina de leucemia de celulas mieloides 1 (MCL-1) siendo util en el tratamiento de cancer de mama, piel, entre otros
