Inc.;The Henry M. Jackson Foundation for the Advancement of Military Medicine
发明人:
George Peoples,Sathibalan Ponniah
申请号：
US14813927
公开号：
US09737596B2
申请日:
2015.07.30
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Provided are methods to induce and maintain a protective cytotoxic T-lymphocyte response to a peptide of the HER2/neu oncogene, GP2, with the effect of inducing and maintaining protective or therapeutic immunity against breast cancer in a patient in clinical remission, including patients having low to intermediate levels of HER2/neu expression. The methods comprise administering to the patient an effective amount of a vaccine composition comprising a pharmaceutically acceptable carrier, an adjuvant such as GM-CSF, and the GP2 peptide. The methods may further comprise administering a periodic booster vaccine dose as needed due to declining GP2-specific T cell immunity. Also provided are vaccine compositions for use in the methods.
