The Henry M. Jackson Foundation for the Advancement of Military Medicine; Inc.
发明人:
Peoples, George E.,Ponniah, Sathibalan
申请号：
AU2015203572
公开号：
AU2015203572A1
申请日:
2015.06.26
申请国别(地区):
AU
年份:
2015
代理人:
摘要：
#$%^&*AU2015203572A120150723.pdf#####ABSTRACT Provided are methods to induce and maintain a protective cytotoxic T-lymphocyte response to a peptide of the HER/neu oncogene, GP2, with the effect of inducing and maintaining protective or therapeutic immunity against breast cancer in a patient in clinical remission, including 5 patients having low to intermediate levels of HER2/neu expression. The methods comprise administering to the patient an effective amount of a vaccine composition comprising a pharmaceutically acceptable carrier, an adjuvant such as GM-CSF, and the GP2 peptide. The methods may further comprise administering a periodic booster vaccine dose as needed due to declining GP2-specific T cell immunity. Also provided are vaccine compositions for use in the 10 methods.
