Inc.;The Henry M. Jackson Foundation for the Advancement of Military Medicine
发明人:
George E. Peoples,Sathibalan Ponniah
申请号：
US14327224
公开号：
US09370560B2
申请日:
2014.07.09
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The invention features methods to induce and maintain a protective cytotoxic T-lymphocyte response to a peptide of the HER2/neu oncogene, E75, with the effect of inducing and maintaining protective or therapeutic immunity against breast cancer in a patient in clinical remission. The methods comprise administering to the patient an effective amount of a vaccine composition comprising a pharmaceutically acceptable carrier, an adjuvant such as recombinant human GM-CSF, and the E75 peptide at an optimized dose and schedule. The methods further comprise administering an annual or semi-annual booster vaccine dose due to declining E75-specific T cell immunity. The invention also features vaccine compositions for use in the methods.
