In this disclosure, a method is described wherein the method comprises mixing a therapeutic gas or a therapeutic liquid or a combination thereof and a liquid carrier in a high shear device to produce a dispersion and administering the produced dispersion intravenously to a patient wherein the produced dispersion contains nanobubbles of the therapeutic gas or droplets of the therapeutic liquid with a mean diameter of less than about 1.5 μm. In this disclosure, a method is described wherein the method comprises mixing a therapeutic gas or a therapeutic liquid or a combination thereof and a liquid carrier in a high shear device to produce a therapeutic fluid, wherein said therapeutic fluid is a solution, a dispersion, or combination thereof and administering the produced therapeutic fluid intravenously to a patient wherein the solution is supersaturated with the therapeutic gas, the therapeutic liquid, or combination thereof.