The present invention relates to a composition for the in vivo degradation of polysaccharide-containing fillers by radical degradation. The composition of the invention comprising at least one source of oxygen free radicals and at least one catalyst of oxygen free radical generation from the at least one source of oxygen free radicals. The present invention further relates to methods and uses of said composition for filler correction or reversal.本發明係關於藉由自由基降解用以活體降解含多醣之充填劑之組合物。本發明組合物包含至少一種氧自由基來源及至少一種自該至少一種氧自由基來源產生氧自由基之觸媒。本發明進一步係關於該組合物用於充填劑矯正或逆轉之方法及用途。