1. It refers to pyridine-3-ethyl ketone (1) derivative of formate with R as hydrocarbon (C1-C6)；1. Cyclopropyl (c3-c8) or cyclopropyl (c3-c8)；X is tar (C1-C6)；Z E, each of which is halogen or asphalt (C1-C6)；N is 0 or 1. 1]] - difluoro (1 - (1 - (4) methyl methyl methyl methyl methyl methyl bromide) base (1 - (1 - (1 -) (1 - (1 -) (1, among other things, pyridine-3-il-acrylate). He also mentioned a pharmaceutical composer These compounds have inhibitory effects on fraction line-cx3cr1 and are useful in the treatment of ulcerative colitis and Crohn's disease.SE REFIERE A COMPUESTOS DERIVADOS DE ACIDO PIRROLIDIN-3-ILACETICO DE FORMULA (1) DONDE R ES ALQUILO(C1-C6), CICLOALQUILO(C3-C8) O CICLOALQUENILO(C3-C8)； X ES ALQUILO(C1-C6)； Z E Y SON CADA UNO HALOGENO O ALQUILO(C1-C6)； n ES 0 O 1. SON COMPUESTOS PREFERIDOS: ACIDO 2-[(3S,4R)-1-{[2-CLORO-6-(TRIFLUOROMETIL)FENIL]METIL}-3-{[1-(2-FLUOROPENTIL)PIPERIDIN-4-IL]CARBAMOIL}-4-METILPIRROLIDIN-3-IL]ACETICO； ACIDO 2-[(3S,4R)-1-[(2,6-DICLOROFENIL)METIL]-3-({1-[(4,4-DIFLUOROCICLOHEXIL)METIL]PIPERIDIN-4-IL}CARBAMOIL)-4-METILPIRROLIDIN-3-IL]ACETICO； ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS TIENEN UN EFECTO INHIBIDOR EN LA RUTA DE FRACTALCINA-CX3CR1 SIENDO UTILES EN EL TRATAMIENTO DE COLITIS ULCEROSA, ENFERMEDAD DE CROHN
