HUANG, TAISHENG,XUE, CHU-BIAO,WANG, ANLAI,KONG, LING,YE, HAI FEN,YAO, WENQING,RODGERS, JAMES D.,SHEPARD, STACEY,WANG, HAISHENG,SHAO, LIXIN,LI, HUI-YIN,LI, QUN
申请号：
PE2012001467
公开号：
PE20130038A1
申请日:
2011.03.09
申请国别(地区):
PE
年份:
2013
代理人:
摘要：
It refers to the Azerbaijani butyltin compound of alachlor-4-il from formula (I), wherein X is n or CR2, R2 is h, halogen, CN, tar (C1-C4),This is, inter Alia, n or CR3, where R3 is h, CN, nitro, alquenilo (C2-C6),Among other things, Z is h, CN, halo, hydrocarbon (C1-C3),L is C (= O), among other things,S (= O) 2, C (= O) or, among other things, a is asphalt (C1-C6),Cyclopropyl (c3-c14),Arilo（C6-C14），R1 is an asphalt (C1-C4), among other things,Hydroxyl, oxygen (C1-C4),F, among other things； n is 0 to 4. ]]]]]]]]]]] - [3 - [3 - [4 - [3 - [3 - [4]]]]] 1. {0} acetone； {3 - {4 - (7h pirrolo) {2} {0} acetone 3 (d) pyridine-4-il-1h-pirazol-1-il] - 1 - [1 - (3,4,5-trifluorobenzoil) piseridin-4-il] azetidin-3-il -, acrylonitrile, etc. He also mentioned a pharmaceutical composer These compounds are active regulators of janisquinasar (Jak1) for the treatment of rheumatoid arthritis, lupus and dermatosis.SE REFIERE A COMPUESTOS DERIVADOS DE PIPERIDIN-4-IL AZETIDINA DE FORMULA (I) DONDE X ES N O CR2, EN DONDE R2 ES H, HALO, CN, ALQUILO(C1-C4), ENTRE OTROS； Y ES N O CR3, EN DONDE R3 ES H, CN, NITRO, ALQUENILO(C2-C6), ENTRE OTROS； Z ES H, CN, HALO, ALQUILO(C1-C3), ENTRE OTROS； L ES C(=O), S(=O)2, C(=O)O, ENTRE OTROS； A ES ALQUILO(C1-C6), CICLOALQUILO(C3-C14), ARILO(C6-C14), ENTRE OTROS； R1 ES ALQUILO(C1-C4), HIDROXILO, ALCOXI(C1-C4), F, ENTRE OTROS； n ES DE 0 A 4. SON COMPUESTOS PREFERIDOS: {1-{1-[3-FLUORO-2-(TRIFLUOROMETIL)ISONICOTINOIL]PIPERIDIN-4-IL}-3-[4-(7H-PIRROLO[2,3-d]PIRIMIDIN-4-IL)-1H-PIRAZOL-1-IL]AZETIDIN-3-IL}ACETONITRILO； {1-[1-(3-FLUORO-4-QUINOLIN-6-ILBENZOIL)PIPERIDIN-4-IL]-3-[4-(7H-PIRROLO[2,3-d]PIRIMIDIN-4-IL)-1H-PIRAZOL-1-IL]AZETIDIN-3-IL}ACETONITRILO； {3-[4-(7H-PIRROLO[2,3-d]PIRIMIDIN-4-IL)-1H-PIRAZOL-1-IL]-1-[1-(3,4,5-TRIFLUOROBENZOIL)PIPERIDIN-4-IL]AZETIDIN-3-IL}ACETONITRILO； ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON MODULADORES DE LA ACTIVIDAD DE JANUS QUINASA (JAK1) SIENDO UTILES EN EL TRATAMIENTO DE ARTRITIS REU
