Provided are systems and methods for pre-qualification of candidate patient populations. The systems and methods can be are configured for inexpensive, selective, and lightweight procedures that identify patients against desired criteria. In some implementations, willing participants are enrolled in pre-treatment execution of a clinical trial. The participants are issued telemedicine monitoring devices for capturing and reporting health information. For example, non-invasive monitoring devices can be issued to track mobility, exertion, blood pressure, heart rate, brain activity, among other options. The participants can be monitored for time periods similar to actual trial execution phases (e.g., monitoring periods of years can be used) or monitored for any length of time to develop comparable clinical histories for the participants.
