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Azol derivative
专利权人:
LTD.;TAISHO PHARMACEUTICAL CO.
发明人:
ONO, NAOYA,KURODA, SHOICHI,SHIRASAKI, YOSHIHISA,TAKAYAMA, TETSUO,SEKIGUCHI, YOSHINORI,USHIYAMA, FUMIHITO,OKA, YUSUKE
申请号:
ES12757646
公开号:
ES2549559T3
申请日:
2012.03.15
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
A compound represented by the formula (1) ** Formula ** where R1 represents the following formula (2) ** Formula ** Ring A represents either one of the rings represented by the following formula (4) ** Formula * * X represents - (CH2) m-X1- (CH2) n-; X1 represents a bond, -O-, -NRaC (>; = O) -, -C (>; = O) NRb-, -NRcS (>; = O) 2-, or -S (>; = O) 2NRd-; Ra, Rb, Rc and Rd which may be the same or different each represent a hydrogen atom or a C1-C6 alkyl group; m and n, which may be the same or different each represent an integer from 0-3; R2 represents an aryl group, a heteroaryl group (said aryl or heteroaryl groups may be substituted with 1-3 substituent groups selected from the group consisting of a halogen atom, a C1-C6 alkyl group, and a C1-C6 alkoxy group ( said C1-C6 alkyl group or C1-C6 alkoxy group may be substituted with 1-3 substituent groups selected from the group consisting of a halogen atom and a hydroxy group)), a 1,3-benzodioxolanyl group, an indolyl group, a morpholyl group, a hydroxy group, a C1-C6 alkyl group (said C1-C6 alkyl group may be substituted with 1-2 hydroxy groups), an amino group, a mono (C1-C6) alkyl amino group, a di- (C1-C6) alkyl amino, a C1-C6 alkoxy group, a (C1-C6) alkyl sulfonyloxy group, a pyridonyl group, or a pyrimidinonyl group or a pharmaceutically acceptable salt thereof.Un compuesto representado por la fórmula (1)**Fórmula** donde R1 representa la siguiente fórmula (2)**Fórmula** el anillo A representa o bien uno de los anillos representados por la siguiente fórmula (4)**Fórmula** X representa -(CH2)m-X1-(CH2)n-; X1 representa un enlace, -O-, -NRaC(>;=O)-, -C(>;=O)NRb-, -NRcS(>;=O)2-, o -S(>;=O)2NRd-; Ra, Rb, Rc y Rd que pueden ser iguales o diferentes representan cada uno un átomo de hidrógeno o un grupo alquilo C1-C6; m y n, que pueden ser iguales o diferentes representan cada uno un número entero de 0-3; R2 representa un grupo arilo, un grupo heteroarilo (dichos grupos arilo o heteroarilo pueden estar s
来源网站:
中国工程科技知识中心
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