ALAM, Jenefer,HO, Soo Yei,WANG, Wei Ling,DURAISWAMY, Athisayamani Jeyaraj,ALAM JENEFER,HO SOO YEI,WANG WEI LING,DURAISWAMY ATHISAYAMANI JEYARAJ
申请号：
ES14870867
公开号：
ES2687493T3
申请日:
2014.12.17
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
Compound of formula (I), ** Formula ** or a pharmaceutically acceptable salt, solvate or polymorph thereof, including all tautomers and stereoisomers thereof, in which: R1 represents H； optionally substituted alkyl (wherein one or more substituents are included among the optional substituents, each of which is independently selected from C1-6 alkoxy, NH2, -NH-C1-3 alkyl and -N (C1-3 alkyl) 2)； -C (O) O-alkyl； haloalkyl, haloalkoxy or -alkylaryl, each R2 independently represents H, optionally substituted alkyl (in which optional substituents include one or more substituents, each independently selected from C1-6 alkoxy, NH2, -NH-C1-3 alkyl and -N (C1-3 alkyl) 2)； -alkylaryl； optionally substituted carbocyclyl (wherein one or more substituents are included among the optional substituents, each independently selected from C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy and halo)； optionally substituted heterocyclyl (in which the optional substituents include one or more substituents each independently selected from C 1-6 alkyl, C 1-6 alkoxy, -C (O) O-C 1-6 alkyl, -C (O) - C1-6 alkyl and C (O) NH-C1-6 alkyl； -NH-alkyl； - N (alkyl) 2； amino, hydroxyl, alkoxy or halo, n represents 0, 1 or 2, R3 represents H or alkyl, R4 represents H or alkyl, R5 represents H or alkyl, W and X each independently represent C>； = O, C>； = S or CH2, Y represents 6-element monocyclic aryl or heteroaryl and Z represents aryl or heteroaryl.Compuesto de fórmula (I), **Fórmula** o una sal, solvato o polimorfo farmacéuticamente aceptable del mismo, incluyendo todos los tautómeros y estereoisómeros de los mismos, en los que: R1 representa H； alquilo sustituido opcionalmente (en el que entre los sustituyentes opcionales se incluyen uno o más sustituyentes, cada uno de los cuales se selecciona independientemente de alcoxi C1-6, NH2, -NH-alquilo C1-3 y -N(alquilo C1-3)2)； -C(O)O-alquilo； haloalquilo, haloalcoxi o -alquilarilo, cada R2 representa independientemente H, alquilo sustituido opc
