BOUILLOT, ANNE MARIE JEANNE,LAROZE, ALAIN,TROTTET, LIONEL
申请号：
ES11168642
公开号：
ES2457521T3
申请日:
2008.11.07
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A compound of formula (I): ** Formula ** in which: X represents -CONH-, -NHCO- or -CH2NH-； R1 represents: -C6-10 aryl optionally substituted with one, two or three groups independently selected from: (a) -C 1-6 alkyl, -OCH3, -C 1-6 alkyl, -C 1-6 haloalkyl, -C3 cycloalkyl -6, -O3-6 cycloalkyl or halogen； (b) phenyl optionally substituted with one, two or three groups independently selected from: halogen； R2 represents -C 1-6 alkyl； R3 represents: -C6-10 aryl optionally substituted with one, two or three groups independently selected from: (a) -C 1-6 alkyl, -C 1-6 alkenyl, -C 1-6 alkoxy, -O (CH 2) mR 4, - (CH2) mOC (>； = O) R4, - (CH2) nCO2R5, - (CH2) nOC (>； = O) R5, -C0-6-OH alkyl, -C (>； = O) NHR6, - (CH2) pNHC (>； = O) R7, -O (CH2) qNR8R9, -O-C1-6-alkyl-OH, -ChaloC 1-6 alkyl, -Ohalo-C 1-6 alkyl, -C3-6 cycloalkyl, -O-C3-6 cycloalkyl or halogen； (b) oxazole； R4 represents -C6-10 aryl； R5 represents -H or -C 1-6 alkyl； R 6 represents -H or -C 1-3 alkyl or -C 1-3 alkyl-OH； R7 represents -H or -C1-3 alkyl； R8 represents -H or -C1-3 alkyl； R9 represents -H or -C1-3 alkyl； m represents 1-3； n represents 0-3； p represents 0-3； and q represents 1-3； or a pharmaceutically acceptable salt thereof.Un compuesto de fórmula (I):**Fórmula** en la que: X representa -CONH-, -NHCO- o -CH2NH-； R1 representa: -arilo C6-10 sustituido opcionalmente con uno, dos o tres grupos seleccionados independientemente de: (a) -alquilo C1-6, -OCH3, -haloalquilo C1-6, -O-haloalquilo C1-6, -cicloalquilo C3-6, -O-cicloalquilo C3-6 o halógeno； (b) fenilo sustituido opcionalmente con uno, dos o tres grupos seleccionados independientemente de: halógeno； R2 representa -alquilo C1-6； R3 representa: -arilo C6-10 sustituido opcionalmente con uno, dos o tres grupos seleccionados independientemente de: (a) -alquilo C1-6, -alquenilo C1-6, -alcoxi C1-6, -O(CH2)mR4, -(CH2)mOC(>；=O)R4, -(CH2)nCO2R5, -(CH2)nOC(>；=O)R5, -alquil C0-6-OH, -C(>；=O)NHR6, -(CH2)pNHC(>；=O)R7, -O(CH2)qNR8R9, -O-alquil C1-6-
