作為新的有生理學價值的硝酰氧基供體的N-羥基磺酰胺衍生物

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专利权人:

THE JOHNS HOPKINS UNIVERSITY

发明人:

Toscano, John, P.,Brookfield, Frederick, Arthur,Cohen, Andrew, D,Courtney, Stephen, Martin,Frost, Lisa, Marie,Kalish, Vincent, Jacob

申请号：

HK13106458.7

公开号：

HK1179509B

申请日:

2013.05.31

申请国别(地区):

HK

年份:

2017

代理人:

摘要：

The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N- hydroxysulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxysulfonamide derivatives.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/