The Johns Hopkins University;Cardioxyl Pharmaceuticals, Inc.
发明人:
申请号：
EP08834117.7
公开号：
EP2190814B1
申请日:
2008.09.26
申请国别(地区):
EP
年份:
2017
代理人:
摘要：
The invention relates to N-hydroxylsulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxylsulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxylsulfonamide derivatives.
