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Aza-bicyclic heterocycles and their use
专利权人:
Bayer Intellectual Property GmbH
发明人:
FOLLMANN, Markus,STASCH, Johannes-Peter,REDLICH, Gorden,ACKERSTAFF, Jens,GRIEBENOW, Nils,KNORR, Andreas,WUNDER, Frank,LI, Volkhart Min-Jian,BÄRFACKER, Lars,WEIGAND, Stefan
申请号:
ES11752194
公开号:
ES2570745T3
申请日:
2011.08.31
申请国别(地区):
ES
年份:
2016
代理人:
摘要:
Compound of formula (I) ** Formula ** in which the P ring represents a group of formula ** Formula ** in which * represents the R2 binding site, represents the R3 binding site, 1 represents the nitrogen atom binding site, 2 represents the carbon atom binding site, Y represents CH, R1 represents hydrogen or fluorine, R2 represents 2-fluorobenzyl, R3 represents a group of formulas ** Formula ** in which it represents the ring-binding site P, L represents N or CH, M represents N or CR4, where R4 represents hydrogen or amino, with the proviso that only one of the groups L and M represents N, A1 represents NR5, where R5 represents hydrogen, A2 represents N, A3 represents N or CR7, where R7 represents hydrogen, fluorine, trifluoromethyl, (C1-C4) alkyl, (C1-C4) alkoxy, amino, methylamino, ethylamino, dimethylamino or diethylamino, which may be substituted (C1-C4) alkyl and (C1-C4) alkoxy on the other hand with 1 or 2 substituents selected ind Ependiently with each other from the group of fluorine, trifluoromethyl, hydroxyl, methoxy and ethoxy, E represents C>; = O, G represents NR12, where R12 represents trideuterometyl, (C1-C6) alkyl, cyclopropyl, cyclobutyl, azetidin-3-yl, pyrrolidin-3-yl or piperidin-4-yl, (C1-C6) alkyl may be substituted with 1 to 3 substituents independently selected from the group of fluorine, trifluoromethyl, cyclopropyl, cyclobutyl, hydroxyl, oxetanyl and morpholin- 1-yl, and azetidin-3-yl, pyrrolidin-3-yl and piperidin-4-yl being substituted with 1 or 2 substituents independently selected from the group of fluorine, trifluoromethyl, 2,2-difluoroethyl, 2 , 2,2-trifluoroethyl, methyl and ethyl, cyclopropyl and cyclobutyl, R11 represents hydrogen R15 represents hydrogen or alkoxycarbonyl (C1-C3), alkoxycarbonyl (C1-C3) being substituted with 1 or 2 substituents independently selected from each other from the group of fluoride, trifluoro methyl, hydroxyl, methoxy and ethoxy, as well as their salts, solvates and solvates of the salts.Compuesto de fór
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