ANTHONY LENNOX MOORE,MARY SUSAN ALBURY,LUKE EDWARD YOUNG,CATHERINE ELLIOTT
申请号：
GB201214938
公开号：
GB2511470A
申请日:
2012.08.22
申请国别(地区):
GB
年份:
2014
代理人:
摘要：
An alternative oxidase (AOX) inhibitor of formula I: wherein R1 is selected from a nitrile group, an alkyl, alkenyl, amine group with 1 to 4 C-atoms that is optionally mono-or polysubsituted by F, O, NH2 or CN, and in which one or more non-adjacent CH2 groups are optionally replaced, in each case independently from one another, by -O-, -NH-, -CO-, -COO-, or -OCO-； R2 is hydrogen or a hydroxy or alkoxy group with 1 to 3 C atoms； R3 is a straight chain or branched alkyl or alkylene with 4 to 20 C atoms, that is optionally mono-or polysubstituted by a C1 to C4 alkyl group； R4 is hydrogen or a hydroxy or alkoxy group with 1 to 3 C atoms； R5 is a halogen group: and R6 is H or a C1 to C4 alkyl group； with the proviso that at least one of R2 and R4 is a hydroxy or alkoxy group with 1 to 3 C atoms. The preferred compound of formula I is Colletochlorin B. These compunds find use in inhibiting a microbial alternative oxidase (AOX) and/or cytochrome bc2 complex. Such compounds find use in agrochemicals and in pharmaceuticals, for treating microbial infections, including fungal infections.
