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Prophylactic and therapeutic treatment of infectious diseases and other diseases with immuno-effector compounds
专利权人:
CORIXA CORPORATION
发明人:
BALDRIDGE, JORY,JOHNSON, DAVID,CLUFF, CHRISTOPHER
申请号:
ES02724914
公开号:
ES2453903T3
申请日:
2002.02.04
申请国别(地区):
ES
年份:
2014
代理人:
摘要:
One or more compounds for use in the treatment, relief or substantial prevention of an infectious disease, autoimmune disease or allergic condition, the formula having one or more compounds: and pharmaceutically acceptable salts thereof, wherein X is a selected member of the group consisting of -O- and -NH-; And it is a member selected from the group consisting of -O- and -S-; R1, R2 and R3 are each members independently selected from the group consisting of acyl (C2-C20); R4 is a member selected from the group consisting of -H and -PO3R7R8, where R7 and R8 are each members independently selected from the group consisting of -H or aliphatic groups (C1-C4); R5 is a member selected from the group consisting of -H, -CH3 and -PO3R9R10, wherein R9 and R10 are each members independently selected from the group consisting of -H and aliphatic groups (C1-C4); R6 is selected from H, OH, oxyaliphatic groups (C1-C4), -PO3R11R12, -OPO3R11R12, -SO3R11, -OSO3R11, -NR11R12, - SR11, -CN, -NO2, -CHO, -CO2R11 and -CONR11R12, in where R11 and R12 are each independently selected from H and aliphatic groups (C1-C4), provided that one of R4 and R5 is a group containing phosphorus and that when R4 is -PO3R7R8, R5 is different from -PO3R9R10, where "* 1", "* 2", "* 3" and "**" represent chiral centers; where n, m, p and q are each independently an integer from 0 to 6, provided that the sum of pym is from 0 to 6, and where the hexapyranoside may be in another configuration than the gluco configuration represented in the formula, selected from alo, altro, hand, gulo, gone, galacto and talo; characterized in that the one or more compounds are administered in the absence of exogenous antigen.Uno o más compuestos para uso en el tratamiento, alivio o prevención sustancial de una enfermedad infecciosa, enfermedad autoinmune o afección alérgica, teniendo el uno o más compuestos la fórmula: y sales farmacéuticamente aceptables de los mismos, en donde X es un miembro seleccionado del grupo que consis
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