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Derivatives of 3-phenylpropionic acid and its use in the treatment of inflammatory bowel disease
专利权人:
ALBIREO AB
发明人:
BROO, ANDERS,GOTTFRIES, JOHAN,KOSSENJANS, MICHAEL,LANNA, LI,LINDSTEDT-ALSTERMARK, EVA-LOTTE,NILSSON, KRISTINA A,OHLSSON, BENGT,THORSTENSSON, MARIA,BOIJE, MARIA
申请号:
ES08724206
公开号:
ES2445049T3
申请日:
2008.03.07
申请国别(地区):
ES
年份:
2014
代理人:
摘要:
A compound of general formula (I) ** Formula ** wherein R1 represents H, F, CH3 or CF3; X represents S, S (O) or SO2; R2 represents linear C1-C6 alkyl or branched C3-C4 alkyl, each optionally substituted by one or more F, or R2 is C1-C3 alkylaryl or C1-C3 alkylheteroaryl, wherein aryl or heteroaryl each is optionally substituted by one or more of the following: halogen, OH, OSO2Rb, C1-C2 alkoxy, C1-C4 alkyl, said C1-C2 alkoxy substituents or C1-C4 alkyl are each optionally substituted by one or more F; R3 is located in the ortho, meta or para position and represents F, C1-C4 alkyl or C1-C2 alkoxy, said C1-C4 alkyl substituents or C1-C2 alkoxy are each optionally substituted by one or more F; or R3 is CH2Ph or NHC (O) OC (CH3) 3; p is an integer from 0-4; L is located in the meta or para position and represents (CH2) nC (O) O (CH2) i, (CH2) nC (O) S (CH2) i, (CH2) nOC (O) (CH2) io (CH2 ) nSC (O) (CH2) i, each optionally substituted on any carbonodisable atom with one or more of the following substituents independently selected from: F, C2-C3 alkenyl, C1-C3 alkyl, C1-C2 alkoxy, said C1-C3 alkyl or C1-C2 alkoxy are each optionally substituted with one or more F, n is an integer from 0-3; i is an integer from 0-3.Un compuesto de fórmula general (I)**Fórmula** en donde R1 representa H, F, CH3 o CF3; X representa S, S(O) o SO2; R2 representa alquilo de C1-C6 lineal o alquilo de C3-C4 ramificado, cada uno opcionalmente sustituido por unoo más F, o R2 es alquilarilo de C1-C3 o alquilheteroarilo de C1-C3, en donde arilo o heteroarilo cada uno estáopcionalmente sustituido por uno o más de los siguientes: halógeno, OH, OSO2Rb, alcoxi de C1-C2, alquilo deC1-C4, dichos sustituyentes alcoxi de C1-C2 o alquilo de C1-C4 están cada uno opcionalmente sustituido poruno o más F; R3 está situado en la posición orto, meta o para y representa F, alquilo de C1-C4 o alcoxi de C1-C2, dichossustituyentes alquilo de C1-C4 o alcoxi de C1-C2 están cada uno opcionalmente sustituido por uno o más
来源网站:
中国工程科技知识中心
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