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INHIBITEURS HETEROCYCLIQUES DE LA GLUTAMINYL CYCLASE (QC, EC 2.3.2.5)
- 专利权人:
- PROBIODRUG AG
- 发明人:
- HEISER, ULRICH,GAERTNER, ULF-TORSTEN,DEMUTH, HANS-ULRICH
- 申请号:
- CA2789440
- 公开号:
- CA2789440C
- 申请日:
- 2011.03.10
- 申请国别(地区):
- CA
- 年份:
- 2020
- 代理人:
- 摘要:
- The invention relates to novel heterocyclic derivatives comprising theformula:(see above formula)as inhibitors of glutaminyl cyclase (QC, EC 2.3.2.5). QC catalyzes theintramolecular cyclization ofN-terminal glutamine residues into pyroglutamic acid (5-oxo-prolyl, pGlu*)under liberation of ammoniaand the intramolecular cyclization of N-terminal glutamate residues intopyroglutamic acid underliberation of water.
- 来源网站:
- 中国工程科技知识中心
- 来源网址:
- http://www.ckcest.cn/home/