HUANG XIANHAI,BRUBAKER JASON,PETERSON SCOTT L,BUTCHER JOHN W,CLOSE JOSHUA T,MARTINEZ MICHELLE,MACCOSS RACHEL NICOLA,JUNG JOON O,SILIPHAIVANH PHIENG,ZHANG HONGJUN,ASLANIAN ROBERT G,BIJU PURAKKATTLE JOH
申请号：
TN2013000471
公开号：
TN2013000471A1
申请日:
2013.11.13
申请国别(地区):
TN
年份:
2015
代理人:
摘要：
The invention provides certain cycloalkyl-fused tetrahydroquinolines of the Formula (I), and their pharmaceutically acceptable salts and esters, wherein R1, R2, R7, R8, R8a, E, Y, Z, n, u, and t are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions associated with with uncontrolled or inappropriate stimulation of CRTH2 function.
