ポジトロン断層撮影法およびポジトロン放出化合物
- 专利权人:
- 国立大学法人;千葉大学
- 发明人:
- 橋本 謙二,豊原 潤
- 申请号：
- JP2010019158
- 公开号：
- JP5618047B2
- 申请日:
- 2010.01.29
- 申请国别(地区):
- JP
- 年份:
- 2014
- 代理人:
- 摘要：
PROBLEM TO BE SOLVED: To provide a positron tomography method that can be applied to diagnosis of concrete brain diseases, and a positron-emitting compound to be used for this method.
SOLUTION: As it is considered that if a substituent having a positron-emitting ability is introduced into a selective ligand of a glycine transporter (GlyT-1) and a positron tomography method is performed, the distribution and an integration density of GlyT-1 in a brain which relate to various diseases could be clarified. researches are performed repeatedly energetically concerning compounds usable in the positron tomography method, and it is found that a compound (I), (II), or (III) in this invention is suitable for the positron tomography method, since the compound is superior in permeability to blood brain barrier, and in addition its selective affinity to GlyT-1 is especially superior.
COPYRIGHT: (C)2011,JPO&INPIT
- 来源网站：
- 中国工程科技知识中心
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