CHEN, CHONYU,陈崇裕,陳崇裕,WANG, HAN CHIEH,王汉杰,王漢傑,WU, JENG HUAH,吴政桦,吳政樺
申请号：
TW098142150
公开号：
TWI379691B
申请日:
2009.12.09
申请国别(地区):
TW
年份:
2012
代理人:
摘要：
A multi-layered liposome structure is a multi-layered spheroid structure including a core layer, a first outer layer, and a second outer layer respectively made of poly(r-glutamic acid)(r-PGA), phospholipids, and poly(r-glutamic acid) hydrogel. A preparation method of the multi-layered liposome structure includes the following steps: a phospholipid film preparation step, a mixing step, and a wrapping step. The phospholipid film preparation step uses a rotary vacuum condensation process to remove solvent contained in the phospholipid solution so that the phospholipids forms a phospholipid thin film on a wall of container. The mixing step adds r-PGA solution into the container having said phospholipid thin film to obtain liposome solution. The wrapping step adds r-PGA hydrogel solution into the liposome solution that is subjected to homogenization to have a hydrogel layer wrapped around an outer layer of the liposome.一種多層微脂粒結構，為一多層球體結構，係包含一中心層、一第一外層及一第二外層，分別為聚麩胺酸、磷脂質及聚麩胺酸水膠。一種多層微脂粒結構之製備方法，其步驟包含：一磷脂質薄膜製備步驟、一混合步驟及一包覆步驟。該磷脂質薄膜製備步驟，以一減壓迴旋濃縮方式去除一磷脂質溶液中的溶劑，使該磷脂質於該容器的瓶壁上形成一層磷脂質薄膜；該混合步驟，將一聚麩胺酸(γ-PGA)溶液加入含有該磷脂質薄膜的容器中，以獲得一微脂粒溶液；及該包覆步驟，將一聚麩胺酸水膠溶液加入該微脂粒溶液中並進行均質，使該微脂粒外層進一步包覆有一水膠層。
