A pharmaceutical composition for use in killing and/or inhibiting the growth and/or proliferation of a microorganism in a subject in need thereof, or for treating a subject afflicted with a microbial infection is disclosed. The composition comprises: (a) an effective amount of an isolated peptide, wherein the peptide comprises the arginine-rich carboxy-terminal region of hepatitis B virus core protein (HBc) and exhibits an antimicrobial activity and (b) a pharmaceutically acceptable carrier. The peptide exhibits an activity against Gram-negative bacteria, Gram-positive bacteria, and/or fungi.一醫藥組成物,用於殺死及/或抑制一需要的個體內一細菌之生長及/或增殖,或用於治療一受細菌感染的個體。該醫藥組成物包含:(a)一有效量之一單離胜肽,其中該單離胜肽包含B型肝炎病毒核蛋白(hepatitis B virus core protein,HBc)之精胺酸密集羧基端區域(arginine-rich carboxy-terminal region),並表現一抗菌活性;以及(b)一藥學上可接受之載體。該單離胜肽表現一抗革蘭氏陰性菌、革蘭氏陽性菌、及/或真菌之活性。
