Keehoon Jung;Sun Chang Kim;Gou Young Koh;Young Jun Koh;Gyun Min Lee
发明人:
Keehoon Jung,Young Jun Koh,Gyun Min Lee,Sun Chang Kim,Gou Young Koh
申请号：
US12636013
公开号：
US08927232B2
申请日:
2009.12.11
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present application describes an isolated nucleic acid molecule encoding a polypeptide capable of synchronously binding VEGF polypeptide and TNF polypeptide comprising: (a) a nucleotide sequence encoding a TNFR2 component and VEGFR1 component operatively linked to (b) a nucleotide sequence encoding a multimerizing component, wherein the TNFR2 component consists essentially of a nucleotide sequence encoding the amino acid sequences of cystein rich domain 1, cystein rich domain 2, cystein rich domain 3, and cystein rich domain 4 of the extracellular domain of TNFR2, and wherein the VEGFR1 component consists essentially of a nucleotide sequence encoding the amino acid sequences of Ig-like domain 2 of the extracellular domain of VEGFR1.
