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СЛИТЫЙ БЕЛОК АНТИАНГИОГЕННОГО ИНДУЦИРУЮЩЕГО ФАКТОРА И ЕГО ПРИМЕНЕНИЕ
专利权人:
ЯНЬТАЙ ЖУНЧАН БАЙОТЕКНОЛОДЖИЗ КО.; ЛТД. (CN)
发明人:
ФАН Цзяньминь (CN),ЛИ Дун (CN)
申请号:
RU2013140472/10
公开号:
RU2013140472A
申请日:
2012.05.18
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. Inhibiting angiogenee fusion protein comprising at least one portion formed from the extracellular domain of VEGFR, and at least one portion formed from the extracellular domain FGFR.gde said portion derived from the extracellular domain of VEGFR, comprises a second Ig-like domain of VEGFR1 or VEGFR2 and third Ig-like domain of VEGFR1 or VEGFR2 said portion derived from the extracellular domain of FGFR, comprising a portion of the intermediate portion resulting from functional sequences Ig-like domain of FGFR, the second Ig-like domain of FGFR and third Ig-like domain FGFR.2. The fusion protein according to Claim. 1, wherein said fusion protein comprises in sequence from the end N to the end of part C derived from the extracellular domain of VEGFR, and a portion derived from the extracellular domain FGFR.3. The fusion protein of claim. 2, where a portion derived from the extracellular domain VEGFR. It comprises sequentially from the end N to the end C of the second Ig-like domain of VEGFR1 or VEGFR2 and third Ig-like domain of VEGFR1 or VEGFR2, and the part derived from the extracellular domain of FGFR, comprising sequentially from the end N to the end of the C portion formed from a portion of the intermediate functional sequence of Ig-like domain of FGFR, the second Ig-like domain of FGFR and third Ig-like domain FGFR.4. The fusion protein of claim 2 or 3 wherein a portion derived from the extracellular domain of VEGFR, further comprising a first Ig-like domain of VEGFR1 or VEGFR2. preferably, the part derived from the extracellular domain of VEGFR, comprises in succession from the end N to the end with the first Ig-like domain of VEGFR1 or VEGFR2, second Ig-like domain of VEGFR1 or VEGFR2 and third Ig-like domain of VEGFR1 or VEGFR2 part derived from the extracellular domain of FGFR, comprising sequentially from the end N to the end of part C, yielding1. Ингибирующий ангиогенеэ слитый белок, содержащий по меньшей мере одну часть, полученную из внеклеточного дом
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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