1. A recombinant binding protein containing an ankyrin repeating domain and a polyethylene glycol moiety of at least 5 kDa, wherein said ankyrin domain binds VEGF-Axxx with below 10M and inhibits the binding of VEGF-Axxx to VEGFR-2.2. The binding protein of claim 1, which has an average molecular weight of at least 100 kDa when analyzed at a concentration of 0.1 mM in PBS at room temperature by gel chromatography using globular proteins as molecular weight standards. The binding protein of claim 1, wherein the N-terminal capping module of said ankyrin repeat domain contains an Asp residue at position 5.4. The binding protein of claim 1, wherein said ankyrin repeating domain competes for binding to VEGF-Axxx with the ankyrin repeating domains of SEQ ID NO: 1 or 3.5. The binding protein of claim 1, wherein said ankyrin repeating domain is selected from the group consisting of ankyrin repeating domains of SEQ ID NO: 1 to 7.6. Binding protein according to any one of paragraphs. 1-5, in which the indicated ankyrin repeating domain is conjugated at its C-terminus by peptide linking to the polypeptide linker and the C-terminal Cys residue, in which the thiol of said C-terminal Cys is further conjugated to maleimide-bound polyethylene glycol. 7 . The binding protein according to claim 6, wherein said maleimide-linked polyethylene glycol is α- [3- (3-maleimido-1-oxopropyl) amino] propyl-co-methoxypolyoxyethylene. The binding protein of claim 1, wherein said binding protein is an ankyrin repeating protein selected from the group consisting of1. Рекомбинантный связывающий белок, содержащий анкириновый повторяющийся домен и полиэтиленгликолевый фрагмент молекулярной массой, по меньшей мере, 5 кДа, где указанный анкириновый домен связывает VEGF-Axxx с Kниже 10М и ингибирует связывание VEGF-Axxx с VEGFR-2.2. Связывающий белок по п. 1, который имеет среднюю молекулярную массу, по меньшей мере, 100 кДа, когда анализируют при концентрации 0,1 мМ в PBS при комнатной температуре путем
