Zhuang Wang,Michael Edward Pacold,Michael Edward Werner,Shrirang Karve
申请号：
US13979271
公开号：
US20140017165A1
申请日:
2012.01.11
申请国别(地区):
US
年份:
2014
代理人:
摘要：
This invention relates generally to the discovery of novel nanoparticles for delivery of DNA double-stranded break (DSB) repair enzyme inhibitors such as wortmannin or wortmannin analogues. In one embodiment, these nanoparticles comprise a polylactide polyglycolide (PLGA) copolymer and a polyethylene glycol (PEG). In addition methods of treatment and methods of enhancing radiation treatments are also provided.
