The present application provides for a compound of Formula I,or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.本案提供式I化合物,或其藥學上可接受之鹽、溶劑化物、及/或酯,含此化合物之組成物,包括投服此化合物之治療方法,及包括投服此化合物與至少一種其它治療劑之治療方法。