The present application provides for a compound of Formula IV,or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.本發明係提供式IV所示的化合物或其藥學上可接受的鹽類、溶劑化物、及/或酯類,含有如是化合物的組成物,包括如是化合物之投藥的治療方法,以及包括如是化合物連同至少一種其他治療劑之投藥的治療方法。