The present application includes a compound of Formula I or II:or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods that includethe administration of such compounds with at least one additional active agent.本案包括式I或II化合物：或其藥學上可接受之鹽、溶劑化物、和/或酯類，含該化合物之組成物，包括投予該化合物之醫療方法，和包括投予該化合物與至少一種額外活性劑之醫療方法。
