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COMPOSES D'IMAGERIE DES PROTEINES TAU QUI S'ACCUMULENT DANS LE CERVEAU
专利权人:
NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES
发明人:
HIGUCHI, MAKOTO,SUHARA, TETSUYA,MARUYAMA, MASAHIRO,CHO, MEIEI,SHIMADA, HITOSHI
申请号:
CA2894994
公开号:
CA2894994C
申请日:
2012.12.21
申请国别(地区):
CA
年份:
2019
代理人:
摘要:
The present invention provides a compound represented by thefollowing formula (1), a pharmaceutically acceptable salt thereof, or asolvatethereof.wherein:R1 and R2 are each separately selected from the group consisting ofhydrogen, alkyl, alkenyl, acyl, and hydroxyalkyl;R3 is hydrogen or halogen;ring A is a benzene ring or a pyridine ring;ring B is selected from the group consisting of the following formulas(iii), and (iv):[Formula 2]in the formula (ii), R a is alkyl;R4 and R5 are each separately selected from the group consisting ofhydrogen, hydroxy, alkoxy, haloalkoxy, halohydroxyalkoxy, and aminoalkyl;andrepresents a double bond or a triple bond. The above compound can be usedas a molecular probe for imaging tau proteins that accumulate in the brain.
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