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M1 muscarinic receptor agonists
专利权人:
Heptares Therapeutics Limited;HEPTARES THERAPEUTICS LTD
发明人:
CONGREVE, Miles,BROWN, Giles,CANSFIELD, Julie,TEHAN, Benjamin,CONGREVE MILES,CONGREVE, MILES,BROWN GILES,BROWN, GILES,CANSFIELD JULIE,TEHAN BENJAMIN
申请号:
ES12794751
公开号:
ES2619829T3
申请日:
2012.11.16
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound of the formula (1): ** Formula ** or a salt thereof, in which: n is 1 or 2; p is 0, 1 or 2; q is 0, 1 or 2; R1 is a C1-10 non-aromatic hydrocarbon group that is optionally substituted with one to six fluorine atoms and wherein one or two, but not all, the carbon atoms of the hydrocarbon group may be optionally substituted by a heteroatom selected from O, N and S and their oxidized forms; R2 is hydrogen or a C1-10 non-aromatic hydrocarbon group; or R1 and R2 together with the nitrogen atom to which they are attached form a non-aromatic heterocyclic group of four to nine ring members, in which the heterocyclic ring may optionally contain a second heteroatom selected from O, N and S and its oxidized forms; and wherein the heterocyclic ring may be optionally substituted with one to six additional substituents selected from C1-2 alkyl; fluorine; and cyano; R3 is selected from hydrogen; halogen; cyano; hydroxy; C1-3 alkoxy; and a C1-5 non-aromatic hydrocarbon which is optionally substituted with one to six fluorine atoms and in which one or two, but not all, the carbon atoms of the hydrocarbon group may be optionally substituted by a heteroatom selected from O, N and S; R4 is a C1-6 non-aromatic hydrocarbon group that is optionally substituted with one to six fluorine atoms and wherein one or two, but not all, the carbon atoms of the hydrocarbon group may be optionally substituted by a heteroatom selected from O, N and S and their oxidized forms; R5 is absent or fluorine; and R6 is absent or fluorine.Un compuesto de la fórmula (1):**Fórmula** o una sal del mismo, en la que: n es 1 o 2; p es 0, 1 o 2; q es 0, 1 o 2; R1 es un grupo hidrocarburo no aromático C1-10 que está opcionalmente sustituido con uno a seis átomos de flúor y en donde uno o dos, pero no todos, los átomos de carbono del grupo hidrocarburo pueden estar sustituidos opcionalmente por un heteroátomo seleccionados entre O, N y S y sus formas oxidadas; R2 es hidrógeno o un grupo hidrocarburo no aromá
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