BROWN, Giles Albert,CANSFIELD, Julie Elaine,CONGREVE, Miles Stuart,PICKWORTH, Mark,TEHAN, Benjamin Gerald
申请号：
ES13766641
公开号：
ES2602039T3
申请日:
2013.09.18
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of the formula (1): ** Formula ** or a salt thereof, in which: p is 0, 1 or 2； X1 and X2 are saturated hydrocarbon groups that together contain a total of five to nine carbon atoms and that are linked together in such a way that the structural unit: ** Formula ** forms a bicyclic ring system； R1 is a C1-10 non-aromatic hydrocarbon group that is optionally substituted with one to six fluorine atoms and in which one or two, but not all, the carbon atoms of the hydrocarbon group may optionally be replaced by a heteroatom selected from O , N and S and oxidized form thereof； R2 is hydrogen or a C1-10 non-aromatic hydrocarbon group； or R1 and R2 together with the nitrogen atom to which they adhere form a four to nine membered non-aromatic heterocyclic ring in the ring, in which the heterocyclic ring may optionally contain a second heteroatom selected from O, N and S and oxidized form thereof； and wherein the heterocyclic ring may optionally be substituted with one to six substituents selected from C1-2 alkyl； fluorine； and cyano； R3 is selected from hydrogen； halogen； cyano； hydroxy； C1-3 alkoxy； and a C1-5 non-aromatic hydrocarbon group that is optionally substituted with one to six fluorine atoms and in which one or two, but not all, the carbon atoms of the hydrocarbon group may optionally be replaced by a heteroatom selected from O, N and S； R4 is a C1-6 non-aromatic hydrocarbon group that is optionally substituted with one to six fluorine atoms and in which one or two, but not all, the carbon atoms of the hydrocarbon group may optionally be replaced by a heteroatom selected from O , N and S and oxidized form thereof； and R5 is fluorine.Un compuesto de la fórmula (1):**Fórmula** o una sal del mismo, en el que: p es 0, 1 o 2； X1 y X2 son grupos de hidrocarburos saturados que juntos contienen un total de cinco a nueve átomos de carbono y que se vinculan entre sí de tal manera que la unidad estructural:**Fórmula** forma un sistema de anillos bicíclicos； R1 es u
