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DERIVE DE PYRAZOLE, COMPOSITION DE MEDICAMENTS CONTENANT LEDIT DERIVE ET INTERMEDIAIRE DE PRODUCTION ASSOCIE
专利权人:
KISSEI PHARMACEUTICAL CO.; LTD.
发明人:
KIKUCHI, NORIHIKO,FUJIKURA, HIDEKI,TAZAWA, SHIGEKI,YAMATO, TOKUHISA,ISAJI, MASAYUKI
申请号:
CA2529878
公开号:
CA2529878C
申请日:
2004.06.15
申请国别(地区):
CA
年份:
2012
代理人:
摘要:
The present invention provides pyrazole derivativesrepresented by the general formula:(see formula I)wherein R1 represents H, an optionally substituted C1-6 alkyl,etc. ; one of Q and T represents a group selected from the following:(see formula II, III, IV, V, VI)and the other represents -Z-Ar wherein Z represents -O-, -S-,etc.; Ar represents an optionally substituted C6-10 aryl, etc.;R represents an optionally substituted C3-8 cycloalkyl, anoptionally substituted C6-10 aryl, etc., pharmaceuticallyacceptable salts thereof, and prodrugs thereof, which exhibitan excellent inhibitory activity in human sodium/glucosecotransporter (SGLT) and are useful as agents for the prevention,inhibition of progression or treatment of a disease associatedwith the excess uptake of at least a kind of carbohydrates selectedfrom glucose, fructose and mannose (diabetes, postprandialhyperglycemia, impaired glucose tolerance, diabeticcomplications, etc.), and pharmaceutical compositionscontaining the same, medicinal uses thereof and intermediatesfor production therefor.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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