UNIVERSIDADE FEDERAL DE SÃO JOÃO DEL REI;UNIVERSIDADE FEDERAL DE OURO PRETO
发明人:
ALEXSANDRO SOBREIRA GALDINO,ANA ALICE MAIA GONÇALVES,JULIANA MARTINS MACHADO,LAÍS MOREIRA NOGUEIRA,LUANA DE SOUSA RAMOS,MARIANA CAMPOS DA PAZ,MILTON HÉRCULES GUERRA DE ANDRADE,NAUHARA VIEIRA DE CASTRO
申请号：
BR102018012803
公开号：
BR102018012803A2
申请日:
2018.06.21
申请国别(地区):
BR
年份:
2020
代理人:
摘要：
synthetic protein, its process of obtaining and its applications related to schistosomiasis this invention refers to an antigenic synthetic protein specially engineered by chemical synthesis containing new epitopes of proteins known to be schistosome immunogenic. it is a synthetic protein containing fused epitopes with different parasite epitopes. this structural characteristic could confer the protein of greater sensitivity and specificity in the recognition of anti-schistosoma antibodies. in addition, the synthetic protein of the present invention may induce a broader immune response, desirable for the treatment of different applications related to the detection, immunization, prevention and treatment of schistosomiasis, which makes it useful in the preparation of different products of interest to industries pharmaceutical and biotechnological, such as in vitro diagnostic kits for the detection of schistosomiasis from physiological samples from humans, as well as immunogenic compositions, vaccines, medications or biopharmaceuticals to prevent and treat this disease. additionally, as an input for the production of monoclonal antibodies. another aspect of the present invention is related to the process of obtaining this protein, based on chemical synthesis in vitro.proteína sintética, seu processo de obtenção e suas aplicações relacionadas à esquistossomose esta invenção refere-se a uma proteína sintética antigênica especialmente engenheirada por síntese química contendo novos epitopos de proteínas reconhecidamente imunogênicas de schistossoma. trata-se de uma proteína sintética contendo epitopos fusionados com diferentes epitopos do parasita. esta característica estrutural poderia conferir a proteína de maior sensibilidade e especificidade no reconhecimento de anticorpos anti-schistosoma. além disso, a proteína sintética da presente invenção poderá induzir uma resposta imune mais ampla, desejável para o atendimento de diferentes aplicações relacionadas à detecção,
