COLTON, CLARK K.,MOSES, JOHN M.,WILSON, VERONICA M.,DALZELL, WILLIAM H.,LAYUROVA, MARIYA,ELIAN, TONY J.,CAI, TRUONG H.,MACKAY, JOHN
申请号：
CA3072322
公开号：
CA3072322A1
申请日:
2018.08.07
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
Chromatography systems and methods for using carbon dioxide to separateone or more cannabis-derived compounds from other components of a mixture aregenerally described. Some of the methods described herein comprisetransporting a mixturecomprising a first cannabis-derived compound and one or more other componentsthrough achromatography column containing a stationary phase comprising a packingmaterial. Insome embodiments, the mixture is transported through the column within amobile phasethat comprises carbon dioxide (e.g., supercritical CO2, liquid CO2). Themobile phase maybe substantially free of a co-solvent that is in liquid phase at standard roomtemperatureand pressure. In some embodiments, the mobile phase is free of any co-solventandcomprises 100 vol% carbon dioxide. The first cannabis- derived compound mayinteract withthe stationary phase and/or the mobile phase to a different degree than theone or more othercomponents of the mixture, causing at least partial separation of the firstcannabis-derivedcompound from the one or more other components within the column. Due to thisseparation, at least one fraction of the mobile phase that comprises the firstcannabis-derivedcompound and is substantially free of the one or more other components of themixture maybe collected.
