System, method and media for quantifying bulbar function of a subject. At a high level, embodiments of the invention measure and quantify bulbar function of a test subject based on video data, audio data, or other sensor data of a subject performing a test of bulbar function, such as speech, swallowing, and orofacial movements. This sensor data is then analyzed to identify key events such as syllable enunciations. Based on one or more characteristics of these key events (such as, for example, their rate, count, assessed accuracy, or trends over time), the bulbar function of the subject can accurately, reliably, and objectively be quantified.