A droplet-size reduction system is described. The system in a first embodiment has a catheter having a distal end and a proximal end and a plurality of lumens therein, a chamber at the proximal end of the catheter, the chamber having a first end and a second end and a fluid pathway therebetween, the first end of the chamber being in fluid communication with the plurality of lumens, an aerosol generator between a first one of the plurality of lumens and the first end of the chamber; and a piezoelectric element disposed in the pathway and coupled to an oscillating voltage supply. In another embodiment, the system has a chamber having a first end and a second end and a fluid pathway therebetween, a plurality of catheters in fluid communication with the first end, an aerosol generator between a first one of the plurality of catheters and the first end, and a piezoelectric element disposed in the pathway and coupled to an oscillating voltage supply. In yet another embodiment, the invention is a method of reducing droplet size in a nebulized medicament, by aerosolizing a liquid medicament to create droplets of the medicament, passing the droplets across a piezoelectric element; and delivering the droplets from the piezoelectric element to a patient.
