The present invention discloses product, such as device, prosthese and material, its surface is through the compound chemical modification with structure-X-R1 after forming the product, wherein X is oxygen, sulphur or NR2 and R1 and R2 independently is hydrogen or the organic group containing any number of carbon atom, to assign these products beneficial characteristic. Compared to the corresponding product for not having the modification, surface modification product has improved biocompatibility. After being implanted into individual, compared to the unmodified product of correspondence, which induces lower foreign body reaction.
