Compounds represented by the general formula (I) or pharmaceutically acceptable salts thereof, which have glucokinase activating activity and are useful as therapeutic agents for diabetes and obesity: (I) wherein R and R are each hydrogen or the like； R is hydrogen, halogeno, or the like； R is hydrogen, lower alkyl, or the like； Q is a carbon, nitrogen, or sulfur atom (with the proviso that the sulfur atom may be mono- or di-substituted with oxo)； R and R are each hydrogen, lower alkyl, or the like； X, X, X and X are each independently carbon or nitrogen； Z is oxygen, sulfur, or nitrogen； Ar is aryl or heteroaryl； A is a 5- or 6-membered nitrogenous aromatic heterocyclic group； m is an integer of 1 to 6； n is an integer of 0 to 3； p is an integer of 0 to 2 (with the proviso that at least two of X to X are each carbon)； and q is 0 or 1.
