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9-MEMBERED FUSED RING DERIVATIVES
专利权人:
发明人:
OHYABU, NAOKI,大薮巨树,大藪巨樹,KURAHASHI, KANA,仓桥香菜,倉橋香菜,NISHIURA, YUJI,西浦佑二,西浦祐二,KATOU, MANABU,加藤学,加藤学,MIYAZAKI, KEISUKE,宫崎圭辅,宮崎圭輔,WADA, TOSHIHIRO,和田俊博,和田俊博,SASAKI, YOSHIKAZU,佐佐木义一,佐佐木義一,IWATSU, MASAFUMI,岩津
申请号:
TW105110183
公开号:
TW201643144A
申请日:
2016.03.30
申请国别(地区):
TW
年份:
2016
代理人:
摘要:
The purpose of the present invention is to provide novel compounds having ACC2 selective inhibitory activity. In addition, the present invention provides a pharmaceutical composition comprising the compound.A compound of Formula: or its pharmaceutically acceptable salt, wherein, R1 is substituted or unsubstituted fused aromatic heterocyclyl represented by Formula: wherein, ring B is 5-membered ring, ring C is 6-membered ring ring A is substituted or unsubstituted non-aromatic carbocycle and the like -L1 - is -O-(CR6R7)m- and the like -L2 - is -O-(CR6R7)n- and the like each R6 is independently hydrogen and the like each R7 is independently hydrogen and the like each m is independently an integer of 0, 1, 2 or 3 each n is independently an integer of 1, 2 or 3 R2 is substituted or unsubstituted alkyl R3 is hydrogen or substituted or unsubstituted alkyl R4 is substituted or unsubstituted alkylcarbonyl and the like.本發明之目的在於提供一種具有ACC2抑制活性之新穎化合物。又,提供一種含有上述化合物之醫藥組合物。本發明係下述式所表示之化合物或其製藥上容許之鹽,(式中,R1為式:(式中,環B表示5員環,環C表示6員環)所表示之經取代或未經取代之縮合芳香族雜環式基,環A為經取代或未經取代之非芳香族碳環等,-L1-為-O-(CR6R7)m-等,-L2-為-O-(CR6R7)n-等,R6各自獨立為氫等,R7各自獨立為氫等,m各自獨立為0、1、2或3之整數,n各自獨立為1、2或3之整數,R2為經取代或未經取代之烷基,R3為氫或者經取代或未經取代之烷基,R4為經取代或未經取代之烷基羰基等)。
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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