The present invention relates to topical ophthalmological pharmaceutical compositions containing regorafenib, a hydrate, solvate or pharmaceutically acceptable salt thereof or a polymorph thereof and its process of preparation and its use for treating ophthalmological disorders.本發明係關於包含雷格拉非尼(Regorafenib)、其水合物、溶劑化物或醫藥上可接受鹽或其多形物之局部眼科醫藥組成物,和其製備方法以及其於治療眼科病症之用途。